Citrix has released a whitepaper titled:"Windows 2008 R2 Optimization Guide For Desktop Virtualization with XenApp 6 / 6.5", the paper which contains 23 pages outlines optimization for XenApp 6 and 6.5 on Windows Server 2008 R2.
The paper starts with recommended GPO’s which can be applied to Windows Server 2008 R2, secondly it provides some recommendations on to be modified registry keys, which preferably can be set using Group Policy Preferences (GPP). It will then provide some registry keys to modify for images deployed using standard disk mode vDisk images using Citrix Provisioning Services.